South Africa detected regional waves on average 7.2 weeks before other countries. We used publicly available data to describe epidemiology, genomic surveillance, and public health and social measures from the first 3 COVID-19 pandemic waves in southern Africa during April 6, 2020–September 19, 2021. Okello) The Global Fund, Geneva, Switzerland (A.F.

Mazibuko) Eswatini Ministry of Health, Lobamba (V. Asiimwe) Eswatini Centers for Disease Control and Prevention, Lobamba, Swaziland (M. Azman) Lesotho Centers for Disease Control and Prevention, Maseru, Lesotho (F. Riek) Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (A.S. McLean) Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia (S.J. Mahomva) US Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.

Mirkovic) Zimbabwe Office of the President and Cabinet, Harare (A. Sinyange) Zimbabwe Centers for Disease Control and Prevention, Harare, Zimbabwe (M. Agolory) Zambia National Public Health Institute (ZNPHI), Lusaka (M. Shoopala) Zambia Centers for Disease Control and Prevention, Lusaka, Zambia (J.Z. Dziuban) Namibia Ministry of Health and Social Services, Windhoek (N. Gudo) Namibia Centers for Disease Control and Prevention, Windhoek, Namibia (E.J. Vergara) Mozambique National Institute for Health, Maputo (A.E. Seitio-Kgokgwe) Mozambique Centers for Disease Control and Prevention, Maputo, Mozambique (A.E. Harvey) Botswana Ministry of Health and Wellness, Gaborone (O. Mwale) Botswana Centers for Disease Control and Prevention, Gaborone, Botswana (T. Frietas) Public Health Institute of Malawi (PHIM), Lilongwe (A.C. Labuda) Angola Ministry of Health, Luanda (E. Auld) Angola Centers for Disease Control and Prevention, Luanda, Angola (A. Miller) Malawi Centers for Disease Control and Prevention, Lilongwe (A.N. Author affiliations: Public Health Institute/US Centers for Disease Control and Prevention Global Health Fellowship Program, Lilongwe, Malawi (J.

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